The GlaxoSmithKline Foundation supports a range of HIV/AIDS-related programs around the world. Since 1998, the GSK France Foundation has supported 86 programs to improve healthcare through prevention, education and training in 14 developing countries. During 2007, 9 new programs were implemented in 5 countries with grants of USD 1,091,461. The GSK Foundation Canada also supports community programs in Africa, including AIDS Orphans Uganda, working with the African Medical Research Foundation (AMREF).

GSK supports community programs in Botswana, Cote d´Ivoire, Ethiopia, Ghana, Kenya, Malawi, Mozambique, Namibia, Nigeria, Senegal, South Africa, Swaziland, Tanzania, Uganda and Zambia. These provide treatment for HIV/AIDS patients, counseling and testing, home-based care, training for health care professionals and community volunteers, life skills training for orphans, hospice care, day care centers, feeding schemes, as well as support for basic primary healthcare and HIV/AIDS clinics.

For example, GSK has supported the AIDS Care Treatment and Support (ACTS) initiative in Masoyi, South Africa, since 1999. GSK provided funds to buy land, build a dedicated HIV/AIDS primary health care clinic and training center, and to cover all running costs for the first three years. The ACTS clinic opened in May 2001 and by the end of 2007 more than 20,000 patients had entered its doors. It is now a specialist HIV primary care clinic, complemented by a home-based care team and an eight-bed community hospice. There are 1,200 patients on ARVs, 100 of which are children under 12. Nearly 2,000 patients are seen each month.

In 2004, GSK´s US Business launched a project called "Hope after HIV: Africa." Through the Children's AIDS Fund, GSK has helped open 6 clinics in Uganda, Malawi, Zambia, and South Africa that have treated more than 9,000 HIV/AIDS patients. The sponsored clinics offer testing, medicines, education, mother-to-child transmission care, counseling and follow-up. Patients are also supported by more than 1,500 volunteers who provide adherence counseling, disease education for family members and palliative care.

GSK has also established the Hope after HIV 501(c)(3) Fund, a charitable program that allows employees and others to donate funds to support life-enhancing, non-medical needs of patients receiving care at the clinics. The fund has been used to improve nutrition and generate income for patients and their families; provide bicycles, pumps and refrigerators; and education for promising young HIV-positive people.