The GlaxoSmithKline Foundation supports a range of HIV/AIDS-related programs around the world. Since 1998, the GSK France Foundation has supported 86 programs to improve healthcare through prevention, education and training in 14 developing countries. The GSK Foundation Canada also supports community programs in Africa, including AIDS Orphans Uganda, working with the African Medical Research Foundation (AMREF).

GSK supports community programs in Botswana, Cote d'Ivoire, Democratic Republic of Congo, Ethiopia, Ghana, Kenya, Malawi, Mozambique, Namibia, Nigeria, Senegal, South Africa, Swaziland, Tanzania, Uganda, Zambia and Zimbabwe. These provide treatment for HIV/AIDS patients, counseling and testing, home-based care, training for health care professionals and community volunteers, life skills training for orphans, hospice care, day care centers, feeding schemes, as well as support for basic primary healthcare and HIV/AIDS clinics.

For example, GSK has supported the AIDS Care Treatment and Support (ACTS) initiative in Masoyi, South Africa, since 1999. GSK's initial support included building a dedicated HIV/AIDS primary health care clinic and training center, and supporting running costs for the first three years. Since the opening of the ACTS clinic in May 2001 more than 28,000 patients have been tested and/or treated. ACTS offer a comprehensive service caring for people at all stages of HIV/AIDS. Facilities and services include a specialist HIV outpatient clinic, complemented by a home-based care team (average of 120 visits per month) an eight-bed community hospice, on-site laboratory, cervical cancer prevention program and a newly established Mother & Child Clinic. There are currently 1,737 patients on ARVs, 152 of which are children under the age of 12 years. Nearly 2,000 patients are seen each month.

In 2004, GSK's US Business launched a project called 'Hope after HIV: Africa'. Through the Children's AIDS Fund, GSK has helped open 6 clinics in Uganda, Malawi, Zambia, and South Africa that have treated more than 9,000 HIV/AIDS patients. The sponsored clinics offer testing, medicines, education, mother-to-child transmission care, counseling and follow-up. Patients are also supported by more than 1,500 volunteers who provide adherence counseling, disease education and palliative care.

GSK has also established the 'Hope after HIV 501(c)(3) Fund' that allows employees and others to donate funds to support life-enhancing, non-medical needs. The fund has been used to improve nutrition and generate income for patients and their families; provide bicycles, pumps and refrigerators; and education for promising young HIV-positive people.